Dalia Mohammed Sherif Elgamil <br/><br/>
Design and synthesis of novel beta - carbolines with pendant heteroaryl as PDE5 inhibitors and anticancer agents /  
Dalia Mohammed Sherif Elgamil ; Supervised Ashraf H. Abadi , Nermin Salah Ahmed 
 - Cairo :   Dalia Mohammed Sherif Elgamil ,   2012 
 - 100 Leaves ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Tadalafil is a Ý - carboline - based phosphodiesterases 5 (PDE5) inhibitor that has been introduced to the market for the treatment of male crectile dysfunction (MED). It sets through elevation of cyclic guanosine monophosphate (cGMP), which leads to vascular relaxation in the corpora cavernosa and penile crection during sexual stimulation