TY - BOOK AU - Dalia Mohammed Sherif Elgamil AU - Ashraf H. Abadi , AU - Nermin Salah Ahmed , TI - Design and synthesis of novel beta - carbolines with pendant heteroaryl as PDE5 inhibitors and anticancer agents / PY - 2012/// CY - Cairo : PB - Dalia Mohammed Sherif Elgamil , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry N2 - Tadalafil is a Ý - carboline - based phosphodiesterases 5 (PDE5) inhibitor that has been introduced to the market for the treatment of male crectile dysfunction (MED). It sets through elevation of cyclic guanosine monophosphate (cGMP), which leads to vascular relaxation in the corpora cavernosa and penile crection during sexual stimulation UR - http://172.23.153.220/th.pdf ER -