TY - BOOK AU - Mohamed Badie Taher Kattaria AU - Eman Abdelghany Abdelghany , AU - Hanan Hosny Afifi , AU - Sawsan Abdelhady Hassan , TI - Micronucleus assay as biomarker for chromosome malsegregation in young mothers with down syndrome children / PY - 2014/// CY - Cairo : PB - Mohamed Badie Taher Kattaria , KW - Chromosome KW - Down syndrome KW - Micronucleus N1 - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD N2 - We observed an increased frequency of binucleated micronucleated lymphocytes in mothers who had a down syndrome (DS) child before 30 years of age and the fluorescence in situ hybridization analysis revealed that micronuclei were mainly originating from malsegregation chromosome 21. The present study included 62 Egyptian young mothers (age < 30 y) ,free from any chronic disease, not taking any regular drugs, there were divided into 2 groups: Group 1; 22 mothers of classic down syndrome children and Group 2; 40 healthy Egyptian matched females as control group ER -