TY  - GEN
AU  - Maha Mohamed Saber Khalil
AU  - AbdelFattah Hassan marrie , 
AU  - Haider Abbas Ghaleb , 
AU  - Sherif Mokhtar , 
TI  - Pharmacogenomics of thrombolytic therapy effect of gene polymorphisms on response to streptokinase in patients with acute myocardial infarction / 
PY  - 2006///
CY  - Cairo : 
PB  - Maha Mohamed Saber Khalil , 
KW  - ACE I / D gene
KW  - Fibrinogen gene
KW  - PAI - 1 gene
KW  - Pharmacogenomics
KW  - Platelet receptor gene
KW  - Thrombolytic therapy
N1  - Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Pharmacology; Issued also as CD
N2  - This study is an attempt to assess the possible effect of 4 different gene polymorphisms on patient's response to streptokinase after acute myocardial infarctionTo achieve this goal , we studied 63 patients with acute anterior myocardial infarction (mean age : 543 ± 972 years , range : 34 - 76 years) , Besides clinical relief of chest pain , patients' response to thrombolytic therapy was evaluated using ST - segment elevation both on admission and 2 hours following SK administrationWe used the ST - segment resolution for assessment of responseFifty percent STR was considered as a sign of effective reperfusionFor each patient DNA was extracted from a peripheral blood sampleFor each gene polymorphism we used the specific primers for Restriction fragment length polymorphism (RFLP) - technique : Polymerase chain reaction (PCR) followed by the specific restriction enzymeOut of the 63 pts studied for ACE insertion / deletion genotyping , fifty percent STR was most frequently observed in 100
ER  -