Aya Zeiada Mohamed <br/><br/>
A comparative randomized study of safety and efficacy of once versus twice daily dose of amikacin in treatment of neonatal sepsis /  
 دراسة مقارنة عشوائية لمدى فاعلية و أمان عقار الأميكيسين كجرعة واحدة أو مزدوجة فى علاج التسمم البكتيرى لدى حديثى الولادة 
Aya Zeiada Mohamed ; Supervised Heba Hany Abu Hussein , Dalia Ahmed Khairy , Rania Ahmed Zayed 
 - Cairo :   Aya Zeiada Mohamed ,   2014 
 - 97 P. ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics 
<br/><br/> Neonates frequently receive amikacin as empiric therapy for severe infections caused by suspected Gram - negative bacteria. Optimum dosing of amikacin is required because of the inter - individual variability in the pharmacokinetics in the neonatal population. This study was conducted to compare the efficacy and safety (nephrotoxicity) of once daily versus twice daily dosing of amikacin in suspected or proven sepsis in neonates in relation to the pharmacokinetics of the drug as well as amikacin pharmacokinetic parameters determination under these two dosing schedules in the septic neonates of the Egyptian population  
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<br/><br/><label>Subjects--Index Terms: </label>Amikacin Aminoglycosides Neonatal sepsis