TY  - BOOK
AU  - Wafaa Abdelmaksoud Mohamed
AU  - Amina Abdelsalam Mahmoud , 
AU  - Rania Ismail Magdy , 
AU  - Rokaya Mohammed Alsayed , 
TI  - A study of the prevalence and risk factors of hepatobiliary dysfunction in Egyptian children with chronic hemolytic anemia / 
PY  - 2014///
CY  - Cairo : 
PB  - Wafaa Abdelmaksoud Mohamed , 
KW  - Chronic hemolytic anemia
KW  - Disorders
KW  - Hepatobiliary
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background: Hepatobiliary involvement in patients with chronic hemolytic anemia is multifactorial and ranges from benign hyperbilirubinemia to potentially hepatic failure and cirrhosis.  Aim & methods: a cross- sectional observational study aimed at the assessment of the prevalence of different forms of hepatobiliary disease among 100 Egyptian children with hereditary chronic hemolytic anemia (45 B-thalassemia, 40 sickle cell anemia, 15 hereditary spherocytosis), and to clarify its features and its possible underlying risk factors.    Results:  symptoms of hepatobiliry dysfunction included abdominal pain in 53%, hepatic symptoms in 58%, and biliary symptoms in 41%. Sixty-six percent patients had elevated AST level, 47% had elevated ALT and 58% has elevated total bilirubin.  Fifty-two patients had abnormal coagulation profile and 21% of 61 subjects were HCV seropositive with hepatomegaly being the only predictor of HCV seropositivity. The prevalence of colelithiasis was 21% and 10% had biliary sludge. Cholithiasis correlated significantly with frequency and duration of transfusion. Multivariate logistic regression analysis showed that abdominal symptoms, hepatomegaly, and prolonged PT/PTT could predict biliary stones. Hepatomegaly detected in 73% patients and multivariate logistic regression analysis showed that abdominal and hepatic symptoms, prolonged PT/PTT and biliary stones could be predictors of hepatomegaly
UR  - http://172.23.153.220/th.pdf
ER  -