Omar Abdellatif Mahmoud Soliman <br/><br/>
Clinicopathological changes associated with gold nanoparticles administration in healthy and  tumor-induced hamsters  /  
 التغيرات الباثولوجية الإكلينيكية المصاحبة لإعطاء جسيمات الذهب النانوية في الهامستر السليمة والمصابة بالأورام 
Omar Abdellatif Mahmoud Soliman ; Supervised Alaa Raafat Ahmed , Adel Khalil Ibrahim , Hazem Mohamed Saleh 
 - Cairo :   Omar Abdellatif Mahmoud Soliman ,   2014 
 - 104 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology 
<br/><br/> Toxicity of gold nanoparticles (GNPs) depends on their size, shape, dose, capping agent, surface chemistry, animal model used, frequency and duration of exposure, and route of administration. In the present study, we investigated the clinicopathological changes associated with administration of GNPs and anti-EGFR-GNPs in healthy and tumor-induced hamsters, respectively. Systemic repeated I/P injection of 18 nm naked GNPs (as verified by transmission electron microscope) at a dose of 30 ppb daily for 2 weeks induced macrocytosis, hypochromasia, leukocytosis, neutrophilia, mild lymphocytosis and monocytosis. Hepatic and renal function parameters remained unchanged in GNPs-treated hamsters when compared to control group 
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<br/><br/><label>Subjects--Index Terms: </label>Clinical biochemistry  Clinical hematology  Gold nanoparticles