TY  - BOOK
AU  - Omar Abdellatif Mahmoud Soliman
AU  - Adel Khalil Ibrahim , 
AU  - Alaa Raafat Ahmed , 
AU  - Hazem Mohamed Saleh , 
TI  - Clinicopathological changes associated with gold nanoparticles{u2019} administration in healthy and  tumor-induced hamsters  / 
PY  - 2014///
CY  - Cairo : 
PB  - Omar Abdellatif Mahmoud Soliman , 
KW  - Clinical biochemistry
KW  - Clinical hematology
KW  - Gold nanoparticles
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology; Issued also as CD
N2  - Toxicity of gold nanoparticles (GNPs) depends on their size, shape, dose, capping agent, surface chemistry, animal model used, frequency and duration of exposure, and route of administration. In the present study, we investigated the clinicopathological changes associated with administration of GNPs and anti-EGFR-GNPs in healthy and tumor-induced hamsters, respectively. Systemic repeated I/P injection of {u2248}18 nm naked GNPs (as verified by transmission electron microscope) at a dose of 30 ppb daily for 2 weeks induced macrocytosis, hypochromasia, leukocytosis, neutrophilia, mild lymphocytosis and monocytosis. Hepatic and renal function parameters remained unchanged in GNPs-treated hamsters when compared to control group
ER  -