Marwa Salah Elsayed Shabana <br/><br/>
Evaluation of the classical complement pathway in activation of rheumatoid arthritis /  
 تقييم المسار الكلاسيكى المتمم فى نشاط الروماتيود المفصلى 
Marwa Salah Elsayed Shabana ; Supervised Samia Mohamad Hassan Fadda , Azza Ahmed Aboulenein , Hanan Elsayed Ali Darweesh 
 - Cairo :   Marwa Salah Elsayed Shabana ,   2014 
 - 136 Leaves :   charts ;   30cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation 
<br/><br/> Complement activation has been implicated in the pathogenesis of RA. C1q  C4 complexes are a specific parameter of classical pathway activation. We aimed to investigate plasma levels of complement parameter; C1q and activated C4 in rheumatoid arthritis, and also to assess their association with disease activity. 50 RA patients classified into inactive RA group whose DAS 28 < 2.6 (n = 23 / 50) and active group had DAS 28  2.6 (n = 27 / 50) and control group (n = 20). RA patients were submitted to full history taking, full clinical examination, routine laboratory investigations, assessment of disease activity. CIq antibodies and C4d antibodies were measured using enzyme - linked Immunosorbent assay (ELISA) technique 
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<br/><br/><label>Subjects--Index Terms: </label>Classical complement pathway Disease activity parameters Rheumatoid arthritis