TY  - BOOK
AU  - Fawzy Abdulmegeed Mohamed Marzouk
AU  - Elsayed Abdelghany Elsayed Ahmed , 
AU  - Maged Mohamed Abdalhakem Barakat , 
AU  - Mohammed Hussain Awwad , 
TI  - Studies on the biodistribution and antioxidant activity of some labelled agents / 
PY  - 2014///
CY  - Cairo : 
PB  - Fawzy Abdulmegeed Mohamed Marzouk , 
KW  - ⁹⁹ {u036B} Tc
KW  - Carnosine
KW  - DMSA
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry; Issued also as CD
N2  - Chelating agents such as carnosine and DMSA can be used in nuclear medicine and biochemical studies. Carnosine was labelled by using tin chloride in presence of glucose as reducing agent and resultant 99mTc - carnosine showed some tumour selectivity. 99mTc (V) DMSA were prepared in high purity by simple decreasing tin content and its biodistribution showed high tumor selectivity. Also the present study investigated that chelating agents impart strong antioxidant activity through inhibition of metal catalyzed fenton reaction. Studied antioxidant parameters such as SOD, MDA, and reduced glutathione and PCR {u2013} RFLP biomarkers as extracellular, tissue and genomic model for measuring oxidative stress showed probable higher antioxidant activity of carnosine than DMSA and maximum protection with dual action of both chelating agent
UR  - http://172.23.153.220/th.pdf
ER  -