Dina Mohamed Mekawi Rabie  <br/><br/>
Cancer tumors growth factor polymorphisms in patients with systemic lupus erythematosus /  
 الانواع الجينية لعامل النمو المبطن للاوعية الدموية فى مرضى الذئبة الحمراء  
Dina Mohamed Mekawi Rabie ; Supervised Laila Ahmed Rashed , Abeer Nabeel Mokbel , Nermeen Mohamed Hassan 
 - Cairo :   Dina Mohamed Mekawi Rabie ,   2014 
 - 131 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Medical Biochemistry 
<br/><br/> Background: VEGF has a role in various diseases involving endothelial cells including lupus glomerulonephritis caused by immune complex deposition.Objectives: to study the association between VEGF polymorphism with susceptibility to SLE as well as lupus nephritis and its relation to VEGF protein level.subjects and methods:Acase control study involving 40 SLE patients without nephritis and 40 SLE patients with nephritis and 20 healthy controls. Polymerase chain reaction and restriction fragment lenght polymorphism(PCR- RFLP)methods were applied to detect polymorphism in VEGF promoter +405 and -460 and VEGF protein  level was measured by ELISA.Results:. There was a significant difference in the VEGF 405 GG  (52.5%)  and VEGF TT 460 (57.5%)  genotypes in lupus nephritis patients compared to the control subjects (35%) ,(45%) respectively 
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Cancer tumors Systemic Lupus Erythematosus Vascular endothelial growth