TY  - BOOK
AU  - Dina Mohamed Mekawi Rabie 
AU  - Abeer Nabeel Mokbel  , 
AU  - Laila Ahmed Rashed , 
AU  - Nermeen Mohamed Hassan , 
TI  - Cancer tumors growth factor polymorphisms in patients with systemic lupus erythematosus / 
PY  - 2014///
CY  - Cairo : 
PB  - Dina Mohamed Mekawi Rabie , 
KW  - Cancer tumors
KW  - Systemic Lupus Erythematosus
KW  - Vascular endothelial growth
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Medical Biochemistry; Issued also as CD
N2  - Background: VEGF has a role in various diseases involving endothelial cells including lupus glomerulonephritis caused by immune complex deposition.Objectives: to study the association between VEGF polymorphism with susceptibility to SLE as well as lupus nephritis and its relation to VEGF protein level.subjects and methods:Acase control study involving 40 SLE patients without nephritis and 40 SLE patients with nephritis and 20 healthy controls. Polymerase chain reaction and restriction fragment lenght polymorphism(PCR- RFLP)methods were applied to detect polymorphism in VEGF promoter +405 and -460 and VEGF protein  level was measured by ELISA.Results:. There was a significant difference in the VEGF 405 GG  (52.5%)  and VEGF TT 460 (57.5%)  genotypes in lupus nephritis patients compared to the control subjects (35%) ,(45%) respectively
ER  -