New routes for synthesis of biologically interestingpolyfunctional heteroaromatics utilizing an enamine precursor /
طرق جديدة لتخليق ا لحلقيات غير المتجانسة عديدة المجموعة الدالة وذات النشاط البيولوجى المتوقع باستخدام الاينامينات كمواد اولية
Amr Salah AbouZeid ; Supervised Mohamed Helmy Elnagdi , Fatma Mohamed Manhi
- Cairo : Amr Salah AbouZeid , 2006
- 157P : ill ; 30cm
Thesis (M.Sc.) - Cairo University - Faculty Of Science - Department Of Organic Chemistry
2 - Acetylnaphthalene 1 condenses with dimethylformamide dimethylacetal (DMFDMA) yielding enaminone 2 , best yield was obtained by heating in a domestic microwave oven at full power for 5 minutes (85in hundred) The formed E enaminone 2 reacted with 2amino4methylthiazole 3 , 4aminopyridine 4 and Osubstituted aniline 5ac yielding the Z enaminones , predomination of Z form due to the fixation of this form by hydrogen bond (cfFigure 1) ; Although 2aminobenzothiazole 9 afforded a mixture of E enaminone 10 and Z - enaminone 11in ratio 4 : 6 as indicated from 1H NMR (cfFigure 2)