Rania Ahmed Talaat Abdelzaher Mohamed <br/><br/>
Detection of hepatitis C virus (HCV) in Saliva with different viral loads in serum of hepatitis C patients /  
 الكشف عن فيروس ج فى لعاب مرشى فيروس ج ذوى المستويات المختلفة من الاصابة الفيروسية فى الدم 
Rania "Ahmed Talaat" Abdelzaher Mohamed ; Supervised Elsayed Tarek Abdelsalam , Maha Mohammed Gaafar 
 - Cairo :   Rania Ahmed Talaat Abdelzaher Mohamed ,   2012 
 - 114 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Botany - Microbiology 
<br/><br/> Hepatitis C virus is the most common cause of liver disease today. Although is believed to primarily transmitted through blood to blood contact, there are indications that other means help in hepatitis C transmission. In nearly half of the cases hepatitis C, the infected individuals cannot identify the source of their infection while it is believed that most cases are due to risk factors involving contaminated blood so it is interested to those concerned with the number one cause of liver disease is possibility of transmitting of Hepatitis C Virus (HCV) via saliva. In this study HCV-RNA in saliva from plasma HCVRNA positive patients was tested by conventional PCR. HCV-RNA was detected in 32out of 49 saliva specimens (65.3%). No correlation was found between the presences of HCV in saliva and age, gender, and transaminase values. A statically significant relation between plasma HCV-RNA viral load and saliva HCV-RNA detection was observed (p=0.034). In conclusion: Although our study supports the concept of shedding of the virus in saliva of HCV patients, more investigations on the biological factors possibly involved in mucosal transmission of HCV are recommended for definitive conclusion 
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<br/><br/><label>Subjects--Index Terms: </label>Hepatitis C virus  Polymerase Chain Reaction  RNA isolation