TY - BOOK AU - Ahmed Mohamed Eldeeb AU - Gamal Eldin Esmat , AU - Mohamed Ali Saber , AU - Wahid Halim Doss , TI - Single nucleotide polymorphism (SNP) rs8099917 as a predictive factor of virological response to pegylated interferon plus ribavirin in treatment of chronic hepatitis C virus patients / PY - 2014/// CY - Cairo : PB - Ahmed Mohamed Eldeeb , KW - HCV KW - Interleukin 28b SNP rs8099917 KW - Pegylated interferon N1 - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine; Issued also as CD N2 - Introduction: For SNP rs8099917, the favorable T allele is associated with a higher SVR after PEG - IFN alpha/RBV therapy while the G allele is a risk factor for non - response. Aim of work: Is to assess the value of (SNP) rs8099917 as a predictor of SVR. Methods: This study is a retrospective controlled study and was performed on a total number of 240 patients who were treated by PEG - IFN alpha/RBV for 48 weeks and (SNP) rs8099917 was done for the all patients. Results: TT genotype was more prevalent in SVR group than TG and GG genotypes. Conclusion: Determination of (SNP) rs8099917 before starting antiviral therapy may thus serve as a good response predictor UR - http://172.23.153.220/th.pdf ER -