Basma Serag Eldin Alsayed Habib <br/><br/>
Synthesis and biological evaluation of some novel phthalimide derivatives incorporated into other heterocycles as anticancer and antimicrobial agents /  
 التشييد و التقييم البيولوجى لبعض مشتقات الفثاليميدات المرتبطة مع حلقات غير متجانسة كمضادات للسرطانات و الميكروبات 
Basma Serag Eldin Alsayed Habib ; Supervised Kamelia Mahmoud Amin , Afaf Hussein Elmasry 
 - Cairo :   Basma Serag Eldin Alsayed Habib ,   2014 
 - 186 P. :   photographs ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry 
<br/><br/> The phthalimide moiety has been utilized extensively in medicinal chemistry and is considered to be a privileged structure that shows various pharmacological activities including anti inflammatory, hypoglycemic, hypolipidemic, anticonvulsant, anxiolytic, antiviral, antitumor and antimicrobial activity. Therefore, we are considered with the synthesis of novel series of substituted (4- substituted phenylamino) methyl phthalimides with the objective of discovering novel antitumor antimicrobial agents. Moreover docking of the some biologically tested compounds into the active site of GyrB enzyme was performed to correlate the docking results with the biological results 
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<br/><br/><label>Subjects--Index Terms: </label>Phthalimides Ring closure reactions Thiazoles and other heterocycles