Mohammed Mustafa Mohammed <br/><br/>
Relationship between matrix metalloproteinase 10 (MMP-10) and atherosclerosis in patients with chronic kidney disease /  
 العلاقة بين مستوى ماتريكس ميتالوبروتيناز- ١٠ و تصلب الشرايين فى مرضى القصر الكلوى المزمن 
Mohammed Mustafa Mohammed ; Supervised Dawlat Belal , Manal Eldeeb , Khalid Kaffas 
 - Cairo :   Mohammed Mustafa Mohammed ,   2014 
 - 184 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine 
<br/><br/> Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD). As matrix metalloproteinases have a major role in atherosclerosis, we investigated the relationship between MMP 10 and severity of atherosclerosis in patients with chronic kidney disease. This was evaluated in a cross sectional, observational study of 30 patients with different stages of kidney disease, 30 patients on dialysis and 20 controls. The severity of atherosclerosis was estimated with carotid intima media thickness (CIMT) by carotid ultrasound. Serum levels of the matrix metalloproteinase 10 (MMP 10) was measured by ELISA and were significantly increased in patients with kidney disease compared with the healthy controls, and higher in patients on dialysis than in earlier stages of CKD 
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<br/><br/><label>Subjects--Index Terms: </label>Atherosclerosis MMP 10 Renal failure