TY  - BOOK
AU  - Asmaa Fawzi Abdelaleem Moustafa
AU  - Alice kamal Abdelaleem , 
AU  - Amr Saad Mohammed , 
AU  - Mohamed Mohamed Mohi Eldin , 
TI  - Assessment of global human DNA - methylation methylenetetrahydrofolate reductase (MTHFR) genetic variants and their role in the development of neural tube defects NTDs / 
PY  - 2014///
CY  - Cairo : 
PB  - Asmaa Fawzi Abdelaleem Moustafa , 
KW  - Global DNA methylation
KW  - MTHFR C677T
KW  - Neural tube defects
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry; Issued also as CD
N2  - Neural tube defects (NTD) are severe, common birth defects that are caused by partial or complete failure of neural tube closure. Our aim of work is to investigate the role of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and global DNA methylation status as factors involved in NTDs etiology. A hospital based case-control study was  performed. Our results showed a significant hypomethylation in NTDs subjects versus control. Direct association between the frequency of 677TT genotype of the MTHFR gene and NTDs has not been demonstrated in our study
UR  - http://172.23.153.220/th.pdf
ER  -