TY - GEN AU - Asmaa Ahmed AbdElAal AU - Laila Abd El Rahman Hegazi , AU - Mervat Mohamed Wageh Mattar , AU - Saher Kamal_Eldin Hussein , TI - Gata 1 and gata 2 gene expression in myelodysplastic syndromes MDS / PY - 2006/// CY - Cairo : PB - Asmaa Ahmed AbdElAal , KW - GATA - 1 KW - GATA - 2 KW - Transcription factors N1 - Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology; Issued also as CD N2 - GATA - 1 and GATA - 2 are 2 transcription factors playing important role in gene regulation during development and differentiation of haematopoietic cellsWhile GATA - 2 is essentially involved in the regulation of proliferation / self renewal of early haematopoietic cells , GATA - 1 is required for terminal differentiationSince inappropriate hematopoietic differentiation results in varying degree of myelodysplasia , which is the hallmark of MDS , GATA - 1 and GATA - 2 genes expression patterns were suspected to be associated with MDS ER -