Desensitization of donor specific resistant positive lymphocyte cross-match by donor specific mesenchymal stem cell transfusion /
إزالة التحسس بإنهاء التفاعل التطابقى الإيجابى للخلايا الليمفاوية بخلايا المتبرع الجزعية
Ahmed Atef Fouad Mekky ; Supervised Mohammed Gamal Aldin Saadi , May Abdelmonem Hasab Allah , Mervat Mohammed Saad Elansary
- Cairo : Ahmed Atef Fouad Mekky , 2014
- 138 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
Background: Donor specific antibodies (DSA) and a positive cross-match in patients who are sensitized through previous blood transfusions, organ transplantation or pregnancy are an important obstacle in kidney transplantation. , trials of allograft transplantation across the HLA barrier have employed desensitization strategies, including the use of plasmapheresis, intravenous immunoglobulins, anti-B-cell monoclonal antibodies and splenectomy, associated with high-intensity immunosuppressive regimens. These measures have proven only partially successful in preventing or treating humoral rejection in high-risk patients, while causing a significant increase in the risk of severe infectious complications occurring after transplantation. Mesenchymal stem cells (MSCs) have immunomodulatory capacity and are able to suppress allo-specific antibody production in vitro, and may therefore help overcome a positive cross-match in sensitized transplant recipients. Aim of the Work: To evaluate the effect of mesenchymal stem cell transfusion on desensitization of donor specific resistant positive lymphocyte cross-match and /or high titre Panel Reactive Antibody (PRA)