TY  - BOOK
AU  - Ahmed Atef Fouad Mekky 
AU  - May Abdelmonem Hasab Allah , 
AU  - Mervat Mohammed Saad El Ansary , 
AU  - Mohammed Gamal Aldin Saadi , 
TI  - Desensitization of donor specific resistant positive lymphocyte cross-match by donor specific mesenchymal stem cell transfusion / 
PY  - 2014///
CY  - Cairo : 
PB  - Ahmed Atef Fouad Mekky  , 
KW  - Desensitisation protocols
KW  - Immunomodulatory properties
KW  - Mesenchymal stem cells
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine; Issued also as CD
N2  - Background: Donor specific antibodies (DSA) and a positive cross-match in patients who are sensitized through previous blood transfusions, organ transplantation or pregnancy are an important obstacle in kidney transplantation. , trials of allograft transplantation across the HLA barrier have employed desensitization strategies, including the use of plasmapheresis, intravenous immunoglobulins, anti-B-cell monoclonal antibodies and splenectomy, associated with high-intensity immunosuppressive regimens. These measures have proven only partially successful in preventing or treating humoral rejection in high-risk patients, while causing a significant increase in the risk of severe infectious complications occurring after transplantation. Mesenchymal stem cells (MSCs) have immunomodulatory capacity and are able to suppress allo-specific antibody production in vitro, and may therefore help overcome a positive cross-match in sensitized transplant recipients. Aim of the Work:  To evaluate the effect of mesenchymal stem cell transfusion on desensitization of donor specific resistant positive lymphocyte cross-match and /or high titre Panel Reactive Antibody (PRA)
ER  -