Noha Mohamed Sayed Mohamed <br/><br/>
Enhancement of cancer therapy using multifunctional gold nanoparticles formulations /  
 تحسين علاج السرطان باستخدام تحضيرات جزيئات الذهب متعددة الوظائف 
Noha Mohamed Sayed Mohamed ; Supervised Ahmed soltan Monem , Nihal Saad Elbialy 
 - Cairo :   Noha Mohamed Sayed Mohamed ,   2014 
 - 207 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics 
<br/><br/> Current non-targeted chemotherapy and radiotherapy  protocols causes marked cytotoxicity to critical organs in human. This thesis advances two multifunctional near infra-red (NIR)  absorbing gold nanoparticles to target breast cancer cells in-vitro and  Ehrlich carcinoma in-vivo. The two developed formulations, gold  nanoshells with mesoporous silica core (PEG-DOX-MPS-GNSs) and  gold nanorods coated mesoporous silica (pGNRs@mSiO2-DOX), can  both convert near infrared light energy into heat causing thermal  damage to cancerous cells. Further, the incorporated mesoporous  silica exhibit high drug loading capacity that can specifically deliver  the anticancer drug doxorubicin into tumor site and release it in  response to the acidic tumor microenvironment  
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<br/><br/><label>Subjects--Index Terms: </label>Cancer  Chemotherapy  Gold nanoparticles