Malignant breast tumours : Role of MRI in predicting histopathological grading /
أورام الثدى الخبيثة : دور الرنين المغناطيسى فى توقع الدرجة الهيستوباثولوجية
Ziad Mahmoud Fouad Gad ; Supervised Maha Hussein Helal , Sahar Mahmoud Mansour , Mervat Mohamed Eldeftar
- Cairo : Ziad Mahmoud Fouad Gad , 2014
- 90 Leaves : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis
To evaluate the correlation between dynamic MRI parameters and ADC values with histological grading in breast cancer. Thirty patients with BIRADS V lesions on mammography were included in the study. MRI examination included conventional sequences; diffusion weighted imaging and dynamic contrast enhanced magnetic resonance imaging. Morphological features, dynamic parameters, and ADC values were recorded and correlated with with the histological grades. A statistically significant inverse correlation between ADC value and histological grade was found. Tumors with higher grade showed lower ADC value compared with those of lower grade (p = 0.001). The mean ADC values of grade I, II and III were 0.96 ± 0.09 x 10⁻³ mm² / s, 0.89 ± 0.11 x 10⁻³ mm² /s and 0.76 ± 0.07 x 10⁻³ mm² / s, respectively. Also, high grade tumors (grade III) were more associated with washout dynamic curve compared to those with lower grades (grades I and II) (p = 0.04). However, no correlation was found between the maximum relative enhancement and the grade