Eman Mohamed Mohamed Abdelaziz  <br/><br/>
Comparison between Pivka-II and interleukin-8 as early diagnostic markers for hepatocellular carcinoma /  
 مقارنة بين بيفيكا -2 والانترلوكين -8 كدلائل اورام للتشخيص المبكر لاورام خلايا الكبد 
Eman Mohamed Mohamed Abdelaziz ; Supervised Ahmed Ebrahim Amin , Olfat Gamil Shaker , Amal Ahmed Mohamed  
 - Cairo :   Eman Mohamed Mohamed Abdelaziz ,   2014 
 - 197 P. :   facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry 
<br/><br/> Hepatocellular carcinoma (HCC) is one of the most aggressive  cancers worldwide. In Egypt, the disease is detected in an advanced stage  at which no treatment may be effective including surgery. Among  Egyptians, viral hepatitis is the most common risk factor for HCC. Early detection of the disease is thus an important goal allowing the patient to be  treated before the enlargement of the tumor or its metastasis to distant  organs. Serum tumor markers may be useful in predicting the tumor at  early stages. The current work aimed to determine the level of  prothrombin induced by vitamin K absence-II (PIVKA-II) and Interleukin  8 (IL-8 ) in sera of patients suffering from HCC & cirrhosis and  comparing which one is more sensitive and specific for early diagnosis of  HCC. The current study was carried out on 120 individuals within three  groups; Normal control, Cirrhosis and HCC groups. Complete  examination was carried out for each individual to confirm diagnosis 
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<br/><br/><label>Subjects--Index Terms: </label>HCC  Interleukin_8  Prothrombin induced by vitamin K absence-II