TY - BOOK AU - Reham Mohamed Gamal AU - Mohammad Elsayed Saleh , AU - Mohammad Hany Gamal Eldin , AU - Moshira Abdelhakim Rateb , TI - Role of renin - angiotensin-aldosterone system in the response of male albino rats to high fat and fructose feeding / PY - 2014/// CY - Cairo : PB - Reham Mohamed Gamal , KW - High - fat - fructose diet KW - Metabolic syndrome KW - Renin - angiotensin II N1 - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology; Issued also as CD N2 - Increased consumption of fat and soft drinks rich in fructose is closely associated with a higher prevalence of metabolic syndrome. The major pathogenesis of metabolic syndrome is the development of insulin resistance caused by the accumulation of visceral fat, which promotes the elevation of blood pressure, dyslipidemia, and dysregulation of glucose metabolism. Expression of all components of the renin{u2013}angiotensin - aldosterone{u2013}system (RAAS) has been shown in adipose tissue of human and rodent models. The present work aimed at studying the effects of inhibition of angiotensin converting enzyme, blocking angiotensin II type 1 receptor, and blocking aldosterone receptor on high fat fructose diet (HFFD) feeding induced-changes in body weight, insulin resistance, and hepatic steatosis in male albino rats. Fifty adult male albino rats were included in this study, divided into five equal groups. Each group contained 10 rats with equal average body weights ER -