Expression of intercellular adhesion molecule - 1 (ICAM -1) in patients with hepatocellular carcinoma /
ا اق اا ر طن ا ا
Somia Saad Abdelshafi Mohemed ; Supervised Amr Saad Mohamed , Mohamed Said Abdelaziz , Amal Ahmed Mohamed
- Cairo : Somia Saad Abdelshafi Mohemed , 2014
- 123 P. : facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
Hepatocellular carcinoma (HCC), the third most common cause of death from cancer worldwide which accounts for 80% - 90% of primary liver cancer, is characterized by a very poor prognosis . Outcome of Hepatocellular carcinoma depends mainly on its early diagnosis. Serum Ü-fetoprotein (AFP) is the only marker that has been widely used for screening and diagnosis of HCCs. However, development of false-negative or false-positive rates with (AFP) was as high as 30% - 40% for patients with small hepatocellular carcinomas. Besides these features, a number of biological markers including cytokines and growth factors have been demonstrated to be increased in the sera of patients with HCC and may be associated with a poor prognosis. Thus the identification of novel biochemical markers for HCC remains an important goal for many laboratories around the world. Intercellular adhesion molecule 1( ICAM - 1) is one of the positive prognostic markers secreted, abundantly in several human tumors including HCC