TY - BOOK AU - Ahmed Ibrahim Amin Ibrahim AU - Foad Abdelmonem Abdallah , AU - Mona Hassan Eltagui , AU - Mona Kamal Elghamrawy , TI - Steady - state serum levels of vascular cell adhesion molecule -1 in children with sickle cell disease : : Relevance to stroke risk and disease severity / PY - 2014/// CY - Cairo : PB - Ahmed Ibrahim Amin Ibrahim , KW - Sickle cell anaemia KW - Stroke KW - VCAM -1 N1 - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD N2 - Our study conducted on 85 patients with SCD aged 2 - 18 years, 8.4% of patients showed high risk study and 12.0% were conditional. One high risk patient had the qualifying velocity in ACA only. Regression analysis showed transfusion and HU dose protective against stroke. Mean VCAM level was 1438.12 ± 848.2 ng / ml and significantly higher than of normal population and higher in patient with normal TCD (P. 038). However, correlation of VCAM level with TAMMvel using showed + ve correlation with (P. 041). Levels were higher in HbSÝ subgroup, higher bilirubin level (and frequency of blood transfusion). In SS subgroup, VCAM level was significantly correlated with severity frequency (P {u2264}. 001) and duration (P {u2264}. 001) of VOCs. Level was lower with HU treatment P. 041 UR - http://172.23.153.220/th.pdf ER -