TY  - BOOK
AU  - Mai Farag Abdelkhalek Kelany 
AU  - Hanan Alhusseini Mohamed  , 
AU  - Iman Maher Mansour  , 
AU  - Rania Mohamed Samy  , 
TI  - Leukemic cell / microenvironment cross talk in acute myeloid leukemia : : Effect on  Cxcl12 level / 
PY  - 2014///
CY  - Cairo : 
PB  - Mai Farag Abdelkhalek Kelany , 
KW  - Acute myeloid leukemia
KW  - Bone marrow
KW  - Homing
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - In the marrow microenvironment, acute leukemia cells are in close contact with marrow stromal cells. Mesenchymal stem cells (MSCs) secrete an array of signaling molecules. Among these factors is the chemokine CXCL12 (SDF-1), whose fine-tuned concentrations in the bone marrow are  critical for maintaining the quiescence, survival and repopulation of hematopoeitic stem cell and leukemic cells through its main receptor, CXCR4. This study aimed to demonstrate the effect of leukemic cells on mesenchymal stromal cell production of CXCL12 through measuring BM  plasma level of CXCL12 in addition to estimate the expression of its gene in  MSCs. This study included 20 AML cases and 10 non neoplastic bone  marrows as a control group
UR  - http://172.23.153.220/th.pdf
ER  -