TY  - BOOK
AU  - Reem Abdelaziz Abousehly
AU  - Ahmed Fouad Aldomairy , 
AU  - Ehab Abdelaziz Ahmed , 
AU  - Nabela Adeb Abdelmeseeh , 
TI  - Structural and androgen receptors changes around the age of puberty in albino rat testis : : A histological and immunohistochemical study / 
PY  - 2014///
CY  - Cairo : 
PB  - Reem Abdelaziz Abousehly , 
KW  - Albino rat testis
KW  - Androgen receptors
KW  - Puberty
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy; Issued also as CD
N2  - The peri-pubertal changes of Androgen receptors (AR) on Sertoli, Leydig and germ  cells were monitored in the Albino rat (Sprague Dawley). Forty Five rats were used  and sub grouped into 3 groups 15 rats each (pre-pubertal, pubertal and post-pubertal). The collected data manifest that AR play a critical role in male fertility since rat  lacking AR showed incomplete germ cell proliferation and lowered testosterone level  resulting in azoospermia and infertility. Germ cells Androgen receptors are not essential for spermatogenesis and normal fertility of rat. Androgens and AR signaling  in Sertoli cells play the most important role in spermatogenesis. Androgen and AR signaling in Leydig cells display autocrine regulation. Lack of functioning AR of Leydig cells exert a major influence on Leydig cell steroidogenic function leading to arrest of spermatogenesis predominately during the spermatid stage
ER  -