TY - BOOK AU - Hesham Abdullah Helmy Eleiwa AU - Ezz Eldin Said Eldenshary , AU - Mohamed Farrag Elyamany , AU - Somaia Ahmad Nada , TI - Evaluation of the therapeutic effect of whey proteins on the hepatotoxicity induced by paracetamol and alcohol Co-administration in rats / PY - 2014/// CY - Cairo : PB - Hesham Abdullah Helmy Eleiwa , KW - Co-administration KW - Hepatotoxicity KW - Paracetamol N1 - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD N2 - Hepatotoxicity induced by oral co-administration of paracetamol (APAP) (500 mg / kg) and alcohol (5 ml/ kg ) to each rat for two and four weeks .On the other hand, oral administration of whey protein isolate (WPI), alpha- lactalbumin (Ü-LA) and beta-lactoglobulin (Ý-LG) are used as therapeutic agents, in two dose levels (100 and 200 mg/kg) after induction of hepatotoxicity in both two and four weeks ,then liver tissue and blood sample collected. Oral administrated of APAP (500 mg / kg ) and alcohol (5 ml/ kg ) for two and four weeks increase in serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST). While, oral administration of WPI, Ü-LA and Ý-LG after APAP and alcohol resulted in reduction in serum AST and ALT activities , serum tumor necrosis factor- alpha (TNF- Ü) and hepatic lipid peroxidation marker malondialdehyde (MDA),while increase oxidative stress biomarkers (hepatic reduced glutathione (GSH) and superoxide dismutase (SOD) UR - http://172.23.153.220/th.pdf ER -