TY  - BOOK
AU  - Doaa Galal Amin Mahmoud 
AU  - Hoda Aboshady , 
AU  - Monira Rageh , 
AU  - Reem Elgebaly , 
TI  - Biophysical studies of melanin nanoparticles as radioprotectors / 
PY  - 2014///
CY  - Cairo : 
PB  - Doaa Galal Amin Mahmoud  , 
KW  - Melanin nanoparticles
KW  - Radioprotectors
KW  - Radiotherapy
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics; Issued also as CD
N2  - During radiotherapy, ionizing irradiation interacts with biological systems to produce free radicals, which attack various cellular components. The hematopoietic system is easily recognized to be radiosensitive and its damage  may be severe. Melanin nanoparticles (MNPs) act as free radical scavengers  prepared by polymerization of dopamine. In this study a total of 110 male  BALB/C mice were divided into five equal groups. Each group contained 22  mice. Mice of group A did not receive MNPs or irradiation (control group),  group B was injected intraperitoneally (i.p.) with 50 mg/kg MNPs. Mice of  group C and D were exposed to a dose of 7 Gy {u0263}-irradiation and injected with  the same dose of MNPs as in group B either 30 min pre- or post-irradiation,  and group E was exposed to a dose of 7 Gy {u0263}-irradiation only. The impact of  MNPs on peripheral blood, spleen and DNA damage induced by irradiation was evaluated by blood count, histopathology of the spleen and comet assay for the  DNA in the bone marrow at 1, 4, 8 and 12 days post-irradiation
ER  -