Doaa Mamdouh Aly Ahmad Abubakr

The role of intercellular adhesion molecule -1 gene polymorphism in the development of cardiovascular disease in egyptian patients with end-stage renal disease / دور تعدد الاشكال الجينى فى الجين المسئول عن جزىء الالتصاق بين الخلايا رقم 1فى حدوث أمراض القلب و الأوعية الدموية فى المرضي المصريين المصابين بالفشل الكلوى المزمن Doaa Mamdouh Aly Ahmad Abubakr ; Supervised Fatma Ahmed Fathy Elmougy , Afaf Ahmed Abdelhady , Rania Kamal Darwish - Cairo : Doaa Mamdouh Aly Ahmad Abubakr , 2014 - 133 P. : charts ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of in Clinical and Chemical Pathology

Background: End-stage renal disease is the most serious consequence of chronic kidney disease. The commonest cause of mortality in end-stage renal disease is cardiovascular diseases. Thus, the pathogenesis of cardiovascular diseases has been extensively studied focusing on genetic factors which have a major role. One of these genetic factors is Intercellular adhesion molecule-1(ICAM-1) gene, particularly single nucleotide polymorphism in ICAM-1 gene called K469 (rs5498). Objective: To study if K469E polymorphism of the ICAM-1 gene is associated with increased cardiovascular disease risk in Egyptian patients with end-stage renal disease



Cardiovascular diseases End-stage renal disease ICAM