TY  - BOOK
AU  - Iman Ahmed Youssef Ahmed Ghannam
AU  - Mona Mores Hanna , 
AU  - Russell J. Cox , 
AU  - Sally Saad Eldin Elnakkady , 
TI  - Studies on the biosynthesis of fusarochromene - A novel metabolite from the sugarcane fungal pathogen fusarium sacchari / 
PY  - 2014///
CY  - Cairo : 
PB  - Iman Ahmed Youssef Ahmed Ghannam , 
KW  - Biosynthesis
KW  - Fusarium sacchari
KW  - Fusarochromene
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - This section includes a survey concerning the anticancer activities of  synthesized and naturally occurring chromenes according to their different mechanisms of actions. In addition, the biosynthetic pathway of chromenes is also cited. This part is interested in the production and isolation of fusarochromene  (FC - A and FC - B), in addition to other secondary metabolites from the fungal culture of Fusarium sacchari. Also, the aim deals with the  investigation of the biosynthetic pathway of the target fusarochromene. This section describes the methods of production and isolation of fusaric acid, 9, 10- dehydro fusaric acid, fusaric acid methyl ester, and  fusarochromene (FC - A, FC - B). It also includes the biosynthetic pathway of FC - A via labelling studies. This section involves the in vitro anticancer screening of fusaric acid, 9, 10- dehydrofusaric acid, fusaric acid methyl ester, FC - A and FC - B against  different human cancer cell lines. A molecular docking study was performed for the target compounds - FC - A and FC - B on Bcl - 2 protein
ER  -