Walaa Mosaad Abuzeid Mohamed <br/><br/>
Prevalence of hepatitis B virus MHR mutations and their correlation with genotypes among chronically infected patients in Egypt /  
 فى فيروس التهاب الكبد الوبائى (ب) و علاقته بالأنماط الجينية للفيروس لدى مرضى العدوى المزمنة فى مصر MHR معدل انتشار طفرات 
Walaa Mosaad Abuzeid Mohamed ; Supervised Dalia Ibrahim Ramadan , Mohamed Abbas Shemis , Abeer Mohamed Mohy 
 - Cairo :   Walaa Mosaad Abuzeid Mohamed ,   2014 
 - 92 Leaves :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Hepatitis B virus is a major health burden in Egypt, with the continuous threat of developing cirrhosis and hepatocellular carcinoma (HCC). The identification of HBV genotypes may help in the early identification of potential sequelae after chronic HBV infection and in implementation of appropriate therapeutic regimens. Mutations within MHR of the hepatitis B surface antigen (HBsAg) were reported to be associated with viral persistence due to vaccine and immunotherapy escape, severity of liver disease and lack of detection by commercial kits. This work aimed to complete data on HBV genotypes, subgenotypes and serotypes circulation in Egypt with recognition of the pattern and prevelance of MHR mutations that might have occurred during the course of the disease.  Eighty-eight chronic HBV infected patients, originating from different geographic parts of Egypt, were recruited for the study. Amplification and partial sequencing of surface protein encoding gene (S gene) in HBV genome was done  
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<br/><br/><label>Subjects--Index Terms: </label>HBV genotypes Major hydrophilic region MHR variants