TY  - BOOK
AU  - Walaa Mosaad Abuzeid Mohamed
AU  - Abeer Mohamed Mohy , 
AU  - Dalia Ibrahim Ramadan , 
AU  - Mohamed Abbas Shemis , 
TI  - Prevalence of hepatitis B virus MHR mutations and their correlation with genotypes among chronically infected patients in Egypt / 
PY  - 2014///
CY  - Cairo : 
PB  - Walaa Mosaad Abuzeid Mohamed , 
KW  - HBV genotypes
KW  - Major hydrophilic region
KW  - MHR variants
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Hepatitis B virus is a major health burden in Egypt, with the continuous threat of developing cirrhosis and hepatocellular carcinoma (HCC). The identification of HBV genotypes may help in the early identification of potential sequelae after chronic HBV infection and in implementation of appropriate therapeutic regimens. Mutations within MHR of the hepatitis B surface antigen (HBsAg) were reported to be associated with viral persistence due to vaccine and immunotherapy escape, severity of liver disease and lack of detection by commercial kits. This work aimed to complete data on HBV genotypes, subgenotypes and serotypes circulation in Egypt with recognition of the pattern and prevelance of MHR mutations that might have occurred during the course of the disease.  Eighty-eight chronic HBV infected patients, originating from different geographic parts of Egypt, were recruited for the study. Amplification and partial sequencing of surface protein encoding gene (S gene) in HBV genome was done
UR  - http://172.23.153.220/th.pdf
ER  -