TY  - BOOK
AU  - Fatma Elzahraa Abdelmoneim Elshafie
AU  - Hazem Elsayed Abou Youssef , 
AU  - Marianne Fathy Ishak Morgan , 
AU  - Randa Fayez Abdelsalam , 
TI  - Taq1 B polymorphism of cholestryl ester transfer protein ; a potential risk factor for atherosclerosis in type 2 diabetes mellitus / 
PY  - 2015///
CY  - Cairo : 
PB  - Fatma Elzahraa Abdelmoneim Elshafie , 
KW  -  T2DM
KW  - SNP:rs708272,c.118+ G277A)
KW  - Vascular complications
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. Cholesteryl ester transfer protein (CETP) plays a major role in cholesterol metabolism, and polymorphisms within its gene may underlie the susceptibility to atherosclerosis. Taq1B polymorphism (SNP:rs708272,c.118+ G277A) is the most widely studied one results from G to A base pair change at nucleotide 277 in intron 1 of the CETP gene which is located on chromosome 16q21. This polymorphism disrupts Taq1 restriction site. The allele containing the Taq1 endonuclease site is called B1, while the allele without the restriction site is called B2. The less common B2 allele has been associated with increased HDL-C levels and decreased CETP activity and levels. The B1 allele of CETP increased the risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) 1.65- and 1.7-fold, respectively. The present study aims to elucidate the association between (SNP:rs708272,c.118+ G277A)  and the prevalence of vascular complications in T2DM.
UR  - http://172.23.153.220/th.pdf
ER  -