Heba Bassiony Atwa Mohamed  <br/><br/>
Evaluation of antitumor potential and expression of p53/p16 genes in Ehrlich solid carcinoma bearing mice treated with magnetite nanoparticles /  
 تقييم التاثير المعالج للورم وتعبير الجنيات بى 53 وبى 16 فى الفئران الحاملة لورم إرليش الصلب المعالجة بجزيئات الماجنتايت النانوية 
Heba Bassiony Atwa Mohamed ; Supervised Mohamed Akmal Elghor , Mona Mostafa Mohamed , Salwa Farouk Sabet  
 - Cairo :   Heba Bassiony Atwa Mohamed  ,   2014 
 - 120 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology 
<br/><br/> Background: Magnetite nanoparticles (MNPs) have been widely used as  contrast agents and have promising approaches in cancer treatment. In the present study we used Ehrlich solid carcinoma (ESC) bearing mice to investigate MNPs antitumor activity and their effect on expression of p53 and  p16 genes as an indicator for apoptotic induction in tumor tissues. Moreover, histopathological effects and DNA damage which may be induced by MNPs were investigated.  Method: MNPs coated with ascorbic acid (size: 25.0 ± 5.0 nm) were synthesized by co-precipitation method and characterized. Mice were treated with 60 mg/Kg MNPs day by day; intratumorally (IT) or intraperitoneally (IP). Tumor size was measured and normal and tumor tissues were taken for subsequent analyses 
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<br/><br/><label>Subjects--Index Terms: </label>Ehrlich tumor  Histology  Magnetite nanoparticles