TY  - BOOK
AU  - Nahla Osama Mohammed Mohammed 
AU  - Ahmed Osman Mostafa , 
AU  - Kamal Mohamed Hamed Dawood , 
AU  - Magda Mahmoud Assem , 
TI  - Expression profiling of some acute myeloid leukemia {u2013} associated markers : : Evaluation of the prognostic potential of these markers / 
PY  - 2015///
CY  - Cairo : 
PB  - Nahla Osama Mohammed Mohammed , 
KW  - Acute Myeloid Leukemia
KW  - ASXL1
KW  - Genetic markers
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry; Issued also as CD
N2  - Acute myeloid leukemia (AML) is a biologically heterogeneous disease of the hematopoietic system characterized by clonal accumulation and expansion of immature myeloid cells within the bone marrow accompanied by impaired normal hematopoiesis. Investigating the etiological causes of AML and the molecular mechanisms, through which the involved genetic defects participate to the onset of the disease, should pave the road toward identifying and development of targeted  therapies that carry the promise to increase the efficacy of the current management regimens. On the molecular level, various genes play a profound role in the progression of the disease (epigenetic effects) and such markers may have strong  potential as molecular diagnostics. Among these markers are ASXL1, PHF6, BAX, and ARC. Fifty recently diagnosed AML patients were enrolled in this study, for whom we evaluated the expression levels of these markers, as determined by their mRNA levels, in AML patients as well as in normal control subjects. Our study indicated that PHF6 and ARC can be used as reliable, independent diagnostic  markers for AML
UR  - http://172.23.153.220/th.pdf
ER  -