TY  - BOOK
AU  - Shaimaa Abdelsattar Abbas Hasan
AU  - Inas Ismail Raafat , 
AU  - Mona Mohamed Kamel  Zoheiry , 
AU  - Safa Sayed Meshaal , 
TI  - Markers of myofibroblast progenitor cells as predictors of HCV-induced hepatic fibrosis and carcinogenesis / 
PY  - 2014///
CY  - Cairo : 
PB  - Shaimaa Abdelsattar Abbas Hasan , 
KW  - EMT
KW  - Liver fibrosis
KW  - TGF-Ý1
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Aim of the work: To analyze the impact of serum biomarkers of EMT on  fibrogenic process and progression to tumorogenesis caused by HCV. Results: The serum TGF-Ý1, BMP-7, CTGF and YKL-40 were  significantly increased in CHC, LC and HCC cases compared with normal  controls (p <0.001). Serum TGF-Ý1/ BMP-7 ratio shows increase from F0 to F4  with no significant difference between LC and HCC. CTGF was significantly  high in LC and YKL-40 was significantly high in HCC.  Conclusions: Increase of TGF-Ý1/BMP-7 ratio reflects the rate of EMT. In  HCV hepatic patients: the simultaneous determination of TGF-Ý1/BMP-7 ratio  and of CTGF in serum might provide information on fibrogenic activity, while  this ratio in association with YKL-40 can be used for monitoring of the malignant  transformation.
UR  - http://172.23.153.220/th.pdf
ER  -