Study of genetic variations in apoptotic genes and hormonal level alterations in hepatitis C patients /
دراسة التغييرات الوراثية فى جينات عملية موت الخلية المبرمج و تغييرات المستوى الهرمونى فى مرضى الإلتهاب الكبدى سى
Ahmed Abdrabou Abdrabou Mohamed ; Supervised Mervat Sayed Mohamed , Olfat Gamil Shaker , Emad Fawzy Eskander
- Cairo : Ahmed Abdrabou Abdrabou Mohamed , 2015
- 195 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
The hepatitis C virus (HCV), the main cause of morbidity and mortality, is endemic worldwide. HCV is most common in underdeveloped nations, with the highest prevalence rates in Egypt. The dual therapy with pegylated-interferon - Ü2b plus ribavirin has markedly improved the clinical outcome of HCV. P53 induces the expression of Fas for triggering apoptosis; an important mechanism for limiting viral replication. This study aims at investigating the impact of P53 rs 1042522 and Fas rs 1800682 genetic polymorphisms at 72 Arg / Pro and -670 A / G respectively on HCV genotype - 4a susceptibility and treatment response. Two hundred and forty volunteers were enrolled in this study and divided into two major groups; the first group was 160 HCV infected patients group and the second group was 80 healthy controls group. HCV patients were sub-divided into two sub - groups; 86 sustained virological responders sub - group and 74 non-responders sub - group