Analytical study for tadalafil (Cialis®) and equivalent compounds /
دراسة تحليلية للتادالافيل (سيالس) و بعض المركبات الشبيهه
Moataz Abdalla Yehia ; Supervised Mohamed Abdelkawy Ibrahim , Mohamed Abdalla Elsayed , Mamdouh Reda Rezk
- Cairo : Moataz Abdalla Yehia , 2015
- 211 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
Four different stability indicating assay methods were developed and validated for the determination of (tadalafil, sildenafil and terazosin) in the presence of its degradation product. The first and second methods was based on the derivative and derivative ratio spectrophotometric technique using acetonitrile: water mixtrure : for tadalafil and methanol as a solvent for both sildenafil and terazosin. In the third method, we used TLC - densitometric technique using high performance thin - layer chromatography plates with a developing system consisting of , and choloroform: acetone: ammonia 6: 4: 0.1, by voiumes