TY  - BOOK
AU  - Abdelrhman Enayet Abdelhamid 
AU  - Mohamed Hassan Nayel  , 
AU  - Mostafa Zein Elabideen Ali , 
AU  - Wael Mokhtar Elmahdy , 
TI  - Management of optic pathway gliomas in pediatric age group / 
PY  - 2015///
CY  - Cairo : 
PB  - Abdelrhman Enayet Abdelhamid , 
KW  - Low grade glioma
KW  - Neurofibromatosis
KW  - Optic pathway glioma
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery; Issued also as CD
N2  - Optic pathway gliomas (OPG) are rare neoplasms in children with an  unpredictable outcome. Because of their natural history and location there is  much controversy about the optimal strategy of management of OPG. We aimed  to present our experience in the management of children with optic pathway  gliomas in the pediatric age group.  Patients and results: Thirty seven patients (18 male/ 19 female) were included in  this study, with a mean age of 5 years. OPG were chiasmatic (n=19), optic nerve  (n=8), hypothalamic (n=5) and chiasmatic/hypothalamic (n=5). Six cases had NFI.  Four cases were surgically debulked and 25 were biopsied (16 open, 8 stereotactic  and one endoscopic) while 7 cases were totally excised. Seven out of 8 optic  nerve tumors were managed by excision and the last one had no surgical  intervention. Twenty six patients received chemotherapy. Histopathology  revealed pilocytic (n=19), pilomyxoid (n=13), fibrillary astrocytoma (n=2) and  grade I papillary-glioneuronal tumor (n=1). Patients suffered from visual affection  (n=27), endocrine dysfunction (n=10) and diencephalon syndrome (n= 2). The  event free survival rates at 1 and 2 years were , 88.3% and 83.4% respectively.  The 2 years overall survival rate was 87.8%. (Mean follow-up duration = 21.5  months).
UR  - http://172.23.153.220/th.pdf
ER  -