TY  - BOOK
AU  - Hend Mostafa Ahmed 
AU  - Fatma Mohamed Taha  , 
AU  - Nabila Abdelaziz Elithy , 
AU  - Olfat Gamil Shaker , 
TI  - Serum hepcidin level as a diagnostic marker in late onset neonatal sepsis / 
PY  - 2015///
CY  - Cairo : 
PB  - Hend Mostafa Ahmed , 
KW  - Diagnostic marker
KW  - late onset neonatal sepsis
KW  - Serum hepcidin
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry; Issued also as CD
N2  - Neonatal sepsis is a clinical syndrome characterized by systemic  signs of circulatory compromise caused by invasion of the blood stream  by bacteria in the first month of life.  The aim of the present work was to assess the diagnostic value of  serum hepcidin as a marker in late onset neonatal sepsis and to compare  the diagnostic values of hepcidin with interleukin-6which is a well- established marker of neonatal sepsis in predicting late onset neonatal  sepsis.  The present study included 2 main groups: infected group (group I)  55% males and 45% females while non-infected control group (group II)  57.5% males and 42.5% females. All groups were subjected to  measurement of hepcidin and interleukin-6 (IL-6) by ELISA technique in  addition to various laboratory investigations diagnosing neonatal sepsis and all  parameters of infection as: red blood cells, hemoglobin, white blood cells,  hematocrit, immature to total neutrophil ratio, platelets, and C-reactive protein  (CRP).  The mean level of hepcidin and IL-6 showed a high significant increase  in infected group than control group (p<0.001). There were significant  positive correlations between hepcidin with IL-6, CRP(p<0.001),  and I/Tratio (p= 0.037),There was a significant negative correlation  between hepcidin and hemoglobin (p= 0.034).
ER  -