Hend Abdelhady Nooh Mahmood <br/><br/>
Baalc gene expression in acute myeloid leukemia and its relation with cd34 expression /  
 اظهار جين ال( بالك) وعلاقته بال( سي دي34) في حالات سرطان الدم الميلودي الحاد 
Hend Abdelhady Nooh Mahmood ; Supervised Tayssir Mohammed Eyada , Hanan Ramadan Nassar , Yomna Mohammed Elmeligui 
 - Cairo :   Hend Abdelhady Nooh Mahmood ,   2015 
 - 126 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology  
<br/><br/> Brain And Acute Leukemia Cytoplasmic (BAALC) gene over-expression has been reported in acute myeloid leukemia (AML). In the present study, BAALC overexpression was investigated by reverse transcriptase- real time quantitative polymerase chain reaction (RT-PCR) in 48 patients with de novo AML.CD34 expression were also analyzed by immunophenotyping. BAALC over-expression was detected in (50%) of the patients while CD34 was positive in (54.3%).In high BAALC expressers patients, was associated with female sex predominance than low BAALC expressers patients and  the difference reach a statistically significant level. High BAALC expression was significantly associated with higher blast percentage in peripheral blood. BAALC over-expression was seen in FAB subtypes MO, M1, M2, M4 and M5 mostly with M1 and M2 and was associated with statistically significant difference between high and low BAALC expressers as regard induction chemotherapy 
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<br/><br/><label>Subjects--Index Terms: </label>Acute myeloid leukemia (AML) Brain And Acute Leukemia Cytoplasmic (BAALC) and Reverse transcriptase  Real time quantitative polymerase chain reaction (RT-PCR)