TY  - BOOK
AU  - Sara Mosaad Mahmoud Rowizak
AU  - Dalia Ahmed Saied , 
AU  - Hanan Al Husseini Alwakeel , 
AU  - Normeen Abd Elhalim Kaddah , 
TI  - Evaluation chitotriosidase activity in pediatric patients with sickle cell anaemia as a predictor of premature atherosclerosis / 
PY  - 2015///
CY  - Cairo : 
PB  - Sara Mosaad Mahmoud Rowizak , 
KW  - Atherosclerosis
KW  - Chitotriosidase enzyme
KW  - Sickle cell disese
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - The pathogenesis of endothelial dysfunction in SCD attracts the attention of investigators{u2019} to the effects of chronic hemolysis on vascular bed integrity and function in patients with congenital hemolytic anemias. Significant elevation in the plasma chitotriosidase enzyme is an established risk factor for venous thrombosis and arteriosclerosis. Objective: This study, aimed to estimate the level of  chitotriosidase activity in pediatric patients with Sickle cell disease as a predictor of the risk of premature atherosclerosis and to evaluate its relation to different clinical ,laboratory parameters in those patients.In addition to measurement of right and left carotid intimal thickness. Methods: Thirty patients  with SCD  were compared with 30 age and sex matched  healthy  subjects  serving as  control.In addition to detailed clinical& laboratory  data, assessment of premature atherosclerosis was performed by measuring  plasma chitotriosidase enzyme activity &carotid intimal thickness by doppler and  the results were correlated  to different clinical & laboratory parameters
ER  -