TY  - BOOK
AU  - Abdallah Mohamed Gamil Abdallah
AU  - Azza Mahmoud Kamel , 
AU  - Gamal Thabet Ali , 
AU  - Raafat Mohamed  Abdelfattah , 
TI  - Role of cytokines genes polymorphisms in predicting the outcome of HLA matched sibling bone marrow transplantation / 
PY  - 2015///
CY  - Cairo : 
PB  - Abdallah Mohamed Gamil Abdallah , 
KW  - Allogeneic HSCT
KW  - GVHD
KW  - Post HSCT complications
N1  - Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology; Issued also as CD
N2  - Graft versus host disease (GVHD) is the major complication of allogeneic  hematopoietic stem cell transplantation (HSCT) and cytokines are  recognized as important mediators of GVHD. Polymorphisms in the  regulatory regions of several cytokine genes have been associated with a  number of immune diseases as well as post HSCT complications. The  aim of this study was the detection of cytokines genes polymorphisms  (CGPs) and their relation to post HSCT complications mainly GVHD in  Egyptian patients receiving HSCT. The study included 106 patient/donor  pairs who received peripheral blood stem cell transplantation (PBSCT)  from HLA-matched identical siblings. DNA for cytokine genotyping was  available for 105 patients and 98 donors only. Polymerase chain reaction  with sequence specific primers (PCR-SSP) technique was used to analyze  the following cytokines genotypes: Tumor necrosis factor-alpha (TNF-Ü)  ({u2212}308), transforming growth factor beta1 (TGF-Ý1) (codon10 and codon  25), interleukin (IL)-6 ({u2212}174), IL-10 ({u2212}1082, {u2212}819 and {u2212}592) and  Interferon {u2013}gamma (IFN-Þ) (+874). From the current study we can  conclude that there was no impact of all tested CGPs on development of  GVHD or other post HSCT complications.
UR  - http://172.23.153.220/th.pdf
ER  -