TY  - BOOK
AU  - Hossam Zakaria Hussein Mohamed
AU  - Tareq Youssef Abdelwahed , 
AU  - Wessam Eldin Salah Eldin Abdelaziz , 
TI  - Tissue simulating phantom for photothermal interaction mediated by nanoparticles / 
PY  - 2015///
CY  - Cairo : 
PB  - Hossam Zakaria Hussein Mohamed , 
KW  - Gold nanoparticles
KW  - Photothermal therapy
KW  - Tissue - simulating phantom
N1  - Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applications in Environmental Metrology, Photochemistry and Agriculture; Issued also as CD
N2  - Photothermal therapy has recently gained a considerable attention particularly after  the revolution of nanomaterials and nanotechnology. The aim of the present work is  to obtain the maximum photothermal response through investigating some effective  parameters of spherical gold nanoparticles like type, size and concentration, as a preclinical study for efficient photothermal therapy. Tissue simulating phantoms based on agar and water media incorporated with two different types of spherical gold nanoparticles, uncoated particles capped with citrate and coated with silica shell, were built. Heat evolution for each type of nanoparticles was recorded in phantom matrix at different particle sizes with different concentrations following irradiation with low laser power of 250 mW, irradiance of 35.4 mW / cm2, and emitting at wavelength of 532 nm. Measurements demonstrated that uncoated spherical gold  nanoparticles showed higher photothermal response than particles coated with silica  shell. Particles with smaller sizes produced more heating effect than those with larger sizes. Only a critical average concentration of NPs is favorable for enhancing  photothermal interaction. Temperature elevation depends on phantom type where higher temperatures were recorded from agar based phantom at each experimental condition. Exponential decay constants based on theoretical calculations demonstrated  that laser attenuation increases with the continuous increase of particle size and concentration
UR  - http://172.23.153.220/th.pdf
ER  -