TY  - BOOK
AU  - Riham Adel Elshiekh 
AU  - Dalia Adel Mohamed Almahdy  , 
AU  - Essam Abdelhamed Abdelsattar  , 
AU  - Mohamed Said Hifnawy , 
TI  - Pharmacognostical study of ochrosia elliptica labill family (Apocynaceae) / 
PY  - 2015///
CY  - Cairo : 
PB  - Riham Adel Elshiekh , 
KW  - Botanical profiling
KW  - Ochrosia elliptica Labill
KW  - Ochrosia elliptica labill family (Apocynaceae)
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy; Issued also as CD
N2  - Botanical profiling including macro-morphological and  micro-morphological study of the different organs of Ochrosia  ellpitica Labill. were done. The ethanolic and aqueous extracts  of the leaves were found to be safe and non-toxic up to 5g/Kg of  body weight. The biological study including anti-inflammatory,  analgesic, cytotoxic, anti-oxidant and antimicrobial activities of  the total ethanolic & aqueous extracts as well as its respective  fractions of the leaves of Ochrosia elliptica Labill. showed that  the methylene chloride fraction was the most active fraction as  anti-inflammatory, cytotoxic and anti-fungal, where the n- butanol fraction was the most active fraction as analgesic, anti- oxidant and anti-fungal. Preliminary phytochemical screening,  proximate analysis, investigation of the lipoidal content,  in addition to phytochemical investigation of the active fractions  which afforded 8 compounds of which lupeol, lupeol acetate,  ursolic acid, uvaol, Ý-sitosterol glucoside and rutin were  reported for the first time from genus Ochrosia as well as, 9- Methoxy and 8-Methoxy ellipticine, the structures of the  isolated compounds were elucidated using different  spectroscopic techniques, were done. Qualitative analysis of the  secondary metabolites of the leaves by LC/MS profiling in both  positive and negative ionization mode were also done and lead  to identification of eight indole alkaloids, two flavonoids, three  phenolic acids and quinic acid. Quantitative estimation of the  total phenolic, flavonoid and alkaloidal content also included in  this study which corresponding to 781.69 ± 0.14, 553.63 ± 0.23  and 20.57 ± 0.87 mg/100 g dry weight, respectively.
UR  - http://172.23.153.220/th.pdf
ER  -