TY  - BOOK
AU  - Safinaz Talaat Anwar
AU  - Ahmed Mahmoud Abdelaziz , 
AU  - Amira Mohamed Bassam , 
AU  - Samia Mohamed Gabal , 
TI  - Evaluation of p27-kip1, Her2/neu and ki-67 expression in breast invasive duct carcinoma / 
PY  - 2015///
CY  - Cairo : 
PB  - Safinaz Talaat Anwar , 
KW  - Breast invasive duct carcinoma
KW  - Cell cycle
KW  - Prognosis
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology; Issued also as CD
N2  - p27 is a negative regulator of cell cycle, considered a tumor suppressor gene and belongs to a family of cyclin-dependent protein kinase inhibitors. The aim of this work is to study the value & importance of p27 expression as a potential prognostic marker in breast invasive duct carcinomas (NST).The examined cases were immunostained by p27 & correlated with established prognostic factors of breast carcinoma (tumor stage, grade, lymph node status, ER, PR, HER2/neu, Ki-67 index). The recorded results show statistically significant relationship between diminished p27 expression and aggressive parameters of the examined tumors. So our conclusion is that p27 is a potential prognostic & predictive marker and may play a role in designing an individually tailored cancer therapy
ER  -