Mona Mohamed Aly Khalifa <br/><br/>
Study of the correlation between homocysteine level and methotrexate-induced neurotoxicity in treated pediatric cancer patients /  
 دراسة العلاقة بين مستوى هوموسيستيين و السمية العصبية الناتجة عن دواء ميثوتركسات المستخدم لعلاج مرضى سرطان الاطفال 
Mona Mohamed Aly Khalifa ; Supervised Sanaa Abdelbaky Kenawy , Wael Zekri Khaled 
 - Cairo :   Mona Mohamed Aly Khalifa ,   2015 
 - 141 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology 
<br/><br/> The present study was designed to deterrmine whether the plasma homocysteine (Hcy) concentration correlates with methotrexate-induced neurotoxicity and to find the relation between the different disease variables (age , CNS status , methotrexale (MTX) dose and initial Hcy concentration) and MTX-induced neurotoxicity or the effect on Hcy concentration. Furthermore, the aim was extended to check out different toxicities occurring with high-dose MTX ( HDMTX ) 
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<br/><br/><label>Subjects--Index Terms: </label>Homocysteine level Methotrexate-induced neurotoxicity Treated pediatric cancer patients